本公司经销AEG-1/LYRIC，AEG-1抗体，克隆类型为polyclonal，宿主来源是Rabbit，AEG-1/LYRICAEG-1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2231R
英文名称：Anti-AEG-1/LYRIC
中文名称：AEG-1抗体
其他名称：Astrocyte elevated gene 1; AEG 1; AEG1; MTDH; AEG1; LYRIC; Protein LYRIC; Lysine-rich CEACAM1 co-isolated protein; 3D3/LYRIC; Metastasis adhesion protein; Metadherin; Astrocyte elevated gene-1 protein; 3D3; Lysine rich CEACAM1 associated protein
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 64kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, cow, dog
产品介绍：LYRIC is a type II membrane protein, the precise role of which has yet to be defined. It is expressed in breast ａnd prostate carcinoma ａnd is a potential mediator of lung metastasis. It has also been found in mouse Purkinje neurons ａnd cerebellum. In epithelial cells it is recruited to tight junctions （TJ） during the maturation of the TJ complexes. LYRIC co-localizes with beta-catenin in normal ａnd tumour tissues.Function : Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B （NF-kappa-B） transcription factor. Promotes anchorage-independent growth of immortalized melanocytes ａnd astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis ａnd also has an effect on bone ａnd brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.Subunit : Interacts with BCIPP, CREBBP/CBP ａnd RELA/p65.Subcellular Location : Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein （By similarity）. Cell junction, tight junction （By similarity）. Nucleus, nucleolus （By similarity）. Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions （TJ） during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain （By similarity）. TNF-alpha causes translocation from the cytoplasm to the nucleus.Tissue Specificity : Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue ａnd small intestine ａnd in endocrine glands such as thyroid ａnd adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma ａnd glioblastoma multiforme.