本公司经销Apelin/Apelin 13，脂肪炎症因子Apelin抗体，克隆类型为polyclonal，宿主来源是Rabbit，Apelin/Apelin 13脂肪炎症因子Apelin抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2425R
英文名称：Anti-Apelin/Apelin 13
中文名称：脂肪炎症因子Apelin抗体
其他名称：AGTRL1 ligand;APEL;APEL_HUMAN;Apelin-13;Apelin13;Apelin 13;APJ endogenous ligand;Apln;XNPEP2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 10kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Apelin is a neuropeptide expressed in the supraoptic ａnd paraventricular nuclei ａnd is an endogenous ligand for APJ, a G protein-coupled orphan receptor which is an alternative coreceptor with CD4 for HIV-1. Apelin ａnd APJ are ubiquitously expressed in peripheral tissues, with highest levels reported for heart ａnd lungs, as well several regions within the central nervous system. The actions of apelin remain largely unknown: Apelin inhibits HIV-1 entry in cells coexpressing CD4 ａnd APJ; the oral intake of Apelin in colostrum ａnd breast milk could have a role in the modulation of the immune responses in neonates; more recent studies have also indicated a role for Apelin in the central control of body fluid homeostasis, by influencing AVP release ａnd drinking behavior. In the cardiovascular system several actions of Apelin have been described, including endothelium-dependent vasodilatation, vasoconstriction through direct action on smooth muscle ａnd positive inotropism.Function : Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 ａnd APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum ａnd the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release ａnd drinking behavior.Subcellular Location : Secreted.Tissue Specificity : Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus ａnd midbrain. Secreted by the mammary gland into the colostrum ａnd the milk.脂肪炎症因子apelin是血管紧张素Ⅱ-1型受体相关蛋白的天然内源性配体，是新发现的小分子活性多肽，为孤儿G蛋白偶联受体一血管紧张素受体AT-1相关蛋白（APJ）的天然配体具有调节心血管系统稳态、扩张血管、降低血压、调节免疫等多种生物学作用。