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货号：BY-0576R
英文名称：Anti-Annexin II/Annexin A2
中文名称：膜粘连蛋白 Ⅱ抗体
其他名称：Annexin A2; ANX 2; ANX2; ANX2L4; ANXA2; arylsulfatase B; CAL1H; Calpactin I heavy chain; calpactin I heavy polypeptide （p36）; chromobindin 8; LIP2; Lipocortin II; LPC2; LPC2D; P36; P36 protein; PAP-IV; placental anticoagulant protein IV; Protein I.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 36kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, dog, cow, shp, chk
产品介绍：The Annexins are a family of structurally similar proteins. Annexins bind to phospholipids ａnd may be involved in regulation of membrane transport, membrane channel activity, ａnd interaction of the cell membrane with the extracellular matrix. Annexin II is a calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. This protein functions as an autocrine factor which heightens osteoclast formation ａnd bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 ａnd 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.信号传导（Signaling Intermediates） Annexin 2是新近发现的纤维蛋白溶解酶原（PLG）和组织型纤溶蛋白溶解酶原激活物（t-PA）的共受体,是Ca2+介导具有高亲和力的磷脂结合蛋白.其介导血管内外纤维蛋白溶解,对保持机体内环境稳定具有重要作用. 依赖性膜磷脂结合蛋白Annexin II调控异常及有害因子的作用,可导致血栓性疾病和动脉硬化症 钙依赖性膜磷脂结合蛋白膜粘连蛋白2异常高表达所引起纤溶亢进,是白血病等恶性肿瘤出血合并症重要机制.钙依赖性磷脂结合蛋白对其干预和调控可能为治疗上述病症提供新思路,为临床治疗开辟新途径.
