本公司经销ATF1，活化转录因子1抗体，克隆类型为polyclonal，宿主来源是Rabbit，ATF1活化转录因子1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0517R
英文名称：Anti-ATF1
中文名称：活化转录因子1抗体
其他名称：Activating Transcription Factor1; TREB36 protein; ATF 1; ATF1 EWS fusion gene ATF1 FUS fusion gene; cAMP dependent transcription factor 1; Cyclic AMP dependent transcription factor ATF 1; Cyclic AMP dependent transcription factor ATF1; EWS AFT1; FUS ATF 1; RNA binding protein activating transcription factor 1 fusion protein; TREB 36; TREB36.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 43kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：ATF1 （Activating Transcription Factor 1, TREB-36） is a member of the ATF/CREB family of basic region leucine-zipper （bZip） DNA-binding proteins that regulates transcription by binding to a consensus cAMP response element （CRE） in the promoter of various viral ａnd cellular genes. Many of these genes are important in cell growth ａnd differentiation, ａnd in stress ａnd immune responses. The activation function of CRE-binding proteins may be modulated by phosphorylation of several kinases ａnd is mediated by coactivators such as CREB-binding protein （CBP） ａnd p300. ATF1 is a nuclear protein that binds DNA as a homodimer or as heterodimers with the inducible transcription factors CREB1 or CREM. Heterodimers appear to be stronger transcriptional activators than the homodimers. Tissue expression of ATF1 mRNA is widespread. Several isoforms of ATF1 arise by differential splicing. ATF1 mediates both Ca2+ ａnd cAMP responses at several levels. It binds to the Tax-responsive element （TRE1） of the human T-cell lymphotropic virus type-I （HTLV1）. ATF1 is detectable in metastatic melanoma cells ａnd seems to contribute to their survival. A chimeric protein composed of the N-terminal domain of EWS （Ewing sarcoma oncogene） linked to the bZip domain of ATF1 is implicated in the rare malignant clear cell sarcoma of tendon sheath ａnd aponeuroses （malignant melanoma of soft parts）.转录调节因子（Transcriptin Regulators） 活化复制因子1（属于activation transcription factor/cAMP responsive element binding protein家族）是真核细胞转录因子，属于ATF/CREB家族。参与由cAMP或某些病毒蛋白质所诱导基因转录的调节。 此抗体识别分子量为43kDa的ATF-1蛋白。 ATF/CREB家族相关蛋白 bs-0517R ATF-1 活化复制因子1 bs-0518R ATF-2 活化复制因子2 bs-0519R ATF-3 活化复制因子3 bs-0035M CREB 非磷酸化环腺苷酸应答元件结合蛋白（抗体） bs-0036R P-CREB 磷酸化环腺苷酸应答元件结合蛋白（抗体）