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Anti-AMACR/P504Sα-甲基酰基辅酶A消旋酶抗体
点击次数：192发布时间：2012/12/26 3:02:39
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-0840R
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货号：BY-0840R
英文名称：Anti-AMACR/P504S
中文名称：α-甲基酰基辅酶A消旋酶抗体
其他名称：alpha-methylacyl-CoA racemase isoform 1; P504S; AMACR; CBAS4; P504S; RACE; 2 arylpropionyl CoA epimerase; Alpha methylacyl Coenzyme A racemase; 2 methylacyl CoA racemase; Alpha methylacyl CoA racemase; EC 5.1.99.4; Macr 1; Macr1; Methylacyl CoA racemase alpha;
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 42kDa
纯化方法：affinity purified by Protein A
交叉反应：mo, rat, hu
产品介绍：alpha-methylacyl-CoA racemase（AMACR/P504S） is Prostate-specific antigen （PSA） screening for prostate cancer is now widespread in the United States among men of all ages. However PSA has limited specificity because benign disease, including prostatic enlargement ａnd inflammation, can increase PSA levels. Thus, a more specific prostate cancer markers is needed. One such potential marker is AMACR, an enzyme that is involved in peroxisomal beta-oxidation of dietary branched-chain fatty acids. Recent studies have shown that, compared with expression in normal or benign prostate epithelium, AMACR is consistently overexpressed in prostate cancer epithelium, making it a specific marker for cancer cells within the prostate gland. Furthermore, overexpression of AMACR may increase the risk of prostate cancer because its expression is increased in premalignant lesions （prostatic intraepithelial neoplasia）.Subcellular Location : Peroxisome. Mitochondrion.Similarity : Belongs to the CaiB/BaiF CoA-transferase family.AMACR的优点在于它是癌症特异性，在癌症组织中高表达。 AMACR亦可用作其他癌症的诊断标志物。对各种癌症细胞进行检查后发现，结肠直肠癌、卵巢癌、乳腺癌、膀胱癌、肺癌、淋巴瘤和黑素瘤都过度表达AMACR，以结肠直肠癌和前列腺癌表达。 AMACR是一种新型前列腺癌标记物，在前列腺癌中胞浆表达较多，正常表到较少.产品图片Antigen: bs-0840P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.
