本公司经销APAF1（NT），凋亡蛋白活性因子-1抗体（N端），克隆类型为polyclonal，宿主来源是Rabbit，APAF1（NT）凋亡蛋白活性因子-1抗体（N端）可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0059R
英文名称：Anti-APAF1（NT）
中文名称：凋亡蛋白活性因子-1抗体（N端）
其他名称：apoptotic peptidase activating factor 1; APAF 1; APAF1; APAF-1; Apoptotic peptidase activating factor 1; Apoptotic protease activating factor 1; Apoptotic protease activating factor; CED 4; CED4; KIAA0413.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 137kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, dog, chk, hrs
产品介绍：Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 （Apaf-3）, leading to the activation of caspase-3 ａnd apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. Subunit is monomer. Oligomerizes upon binding of cytochrome c ａnd dATP. Oligomeric Apaf-1 ａnd pro-caspase-9 bind to each other via their respective N-terminal CARD domains ａnd consecutively mature caspase-9 is released from the complex. Pro-caspase-3 is recruited into the Apaf-1-pro-caspase-9 complex via interaction with pro-caspase-9. [tissue specificity] Ubiquitous. Highest levels of expression in adult spleen ａnd peripheral blood leukocytes, ａnd in fetal brain, kidney ａnd lung. Isoform 1 is expressed in heart, kidney ａnd liver.Function : Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 （Apaf-3）, leading to the activation of caspase-3 ａnd apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.Subunit : Monomer. Oligomerizes upon binding of cytochrome c ａnd dATP. Oligomeric Apaf-1 ａnd pro-caspase-9 bind to each other via their respective NH2-terminal CARD domains ａnd consecutively mature caspase-9 is released from the complex. Pro-caspase-3 is recruited into the Apaf-1-pro-caspase-9 complex via interaction with pro-caspase-9. Interacts with APIP. Interacts （via CARD ａnd NACHT domains） with NAIP/BIRC1 （via NACHT domain）.Subcellular Location : CytoplasmTissue Specificity : Ubiquitous. Highest levels of expression in adult spleen ａnd peripheral blood leukocytes, ａnd in fetal brain, kidney ａnd lung. Isoform 1 is expressed in heart, kidney ａnd liver.Similarity : Contains 1 CARD domain. Contains 1 NB-ARC domain. Contains 13 WD repeats.Apaf-1 （Apoptosis protease activating factor-1）调节细胞色素C依赖的Caspase-9原的自动催化活性，导致Caspase-3 的激活和引起凋亡。Apaf-1在成年人的脾脏、外周血白细胞、肾脏、肺和胎儿脑、肾、肺中高水平表达。