本公司经销Activated protein C/PROC1，活化蛋白C抗体，克隆类型为polyclonal，宿主来源是Rabbit，Activated protein C/PROC1活化蛋白C抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0040R
英文名称：Anti-Activated protein C/PROC1
中文名称：活化蛋白C抗体
其他名称：Protein C;Activation peptide; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV; EC 3.4.21.69; PC; PROC; PROC1; Vitamin K dependent protein C precursor; Activation peptide;Anticoagulant protein C;APC;Autoprothrombin IIA;Blood coagulation factor XIV;EC 3.4.21.69;PC;proC;PROC_HUMAN;PROC1;Protein C （inactivator of coagulation factors Va ａnd VIIIa）;Vitamin K dependent protein C;Vitamin K dependent protein C precursor.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 52kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow, chk, pig
产品介绍：Protein C is a vitamin K dependent serine protease zymogen. Purified human activated protein C selectively destroys factors Va ａnd VIII:C in human plasma ａnd thus has an important anticoagulant role. Protein C deficiency has been associated with inherited thrombophilia. In its primary structure, protein C is similar to the prothrombin group of blood coagulation factors. It most closely resembles factor X. Protein C is synthesized as a single chain; this precursor molecule is cleaved into a light chain ａnd a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain.Involvement in disease:Defects in PROC are the cause of protein C deficiency autosomal dominant （ADPROCD）. ADPROCD is a cause of hereditary thrombophilia, a hemostatic disorder characterized by impaired regulation of blood coagulation ａnd a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency ａnd those with normal amounts of a functionally defective protein as having type II deficiency.Defects in PROC are the cause of protein C deficiency autosomal recessive （ARPROCD） . ARPROCD results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare.Function : Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va ａnd VIIIa in the presence of calcium ions ａnd phospholipids.Subunit : Synthesized as a single chain precursor, which is cleaved into a light chain ａnd a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain; this reaction, which occurs at the surface of endothelial cells, is strongly promoted by thrombomodulin.Tissue Specificity : Plasma; synthesized in the liver.DISEASE : [DISEASE] Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal dominant （THPH3） [MIM:176860]. A hemostatic disorder characterized by impaired regulation of blood coagulation ａnd a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency ａnd those with normal amounts of a functionally defective protein as having type II deficiency. Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal recessive （THPH4） [MIM:612304]. A hemostatic disorder characterized by impaired regulation of blood coagulation ａnd a tendency to recurrent venous thrombosis. It results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare.Similarity : Belongs to the peptidase S1 family. Contains 2 EGF-like domains. Contains 1 Gla （gamma-carboxy-glutamate） domain. Contains 1 peptidase S1 domain.活化蛋白C是一种丝氨酸蛋白酶，也是一种抑癌基因，参与细胞信号的传导，在细胞分裂、细胞黏附中有重要的作用 有人用于抑制凝血 （抗凝作用）促进纤维蛋白溶解及抗炎作用的研究, 近年来有学者认为APC还可以抑制血管内皮细胞凋亡, 有抑制肿瘤坏死因子产生、限制凝血酶诱导炎症反应与微血管内皮细胞的一些作用。产品图片Tissue/cell: rat colitis tissue;4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-Activated protein C/PROC1 Polyclonal Antibody, Unconjugated（bs-0040R） 1:200, overnight at 4°C; The secondary antibody was Goat Anti-Rabbit IgG, PE conjugated （bs-0295G-PE）used at 1:200 dilution for 40 minutes at 37°C. Tissue/cell: Human brain glioma tissue; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-Activated protein C/PROC1 Polyclonal Antibody, Unconjugated（bs-0040R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） stainingAntigen: bs-0040P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti- Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.