本公司经销AGT，血管紧张素原抗体，克隆类型为polyclonal，宿主来源是Mouse，AGT血管紧张素原抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0045M
英文名称：Anti-AGT
中文名称：血管紧张素原抗体
其他名称：Angiotenogen; Angiotensinogen; AT.
抗体来源：Mouse
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 49kDa
纯化方法：affinity purified by Protein A
交叉反应：mo, rat, hu
产品介绍：Angiotensinogen protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver ａnd is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I is then cleaved by angiotensin converting enzyme （ACE） to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure ａnd in the pathogenesis of essential hypertension ａnd preeclampsia.Function : Essential component of the renin-angiotensin system （RAS）, a potent regulator of blood pressure, body fluid ａnd electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 （angiotensin 1-10）. Angiotensin-1 is a substrate of ACE （angiotensin converting enzyme） that removes a dipeptide to yield the physiologically active peptide angiotensin-2 （angiotensin 1-8）. Angiotensin-1 ａnd angiotensin-2 can be further processed to generate angiotensin-3 （angiotensin 2-8）, angiotensin-4 （angiotensin 3-8）. Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME （neprilysin）. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility ａnd heart rate through its action on the sympathetic nervous system, ａnd alters renal sodium ａnd water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize ａnd secrete aldosterone. Angiotensin-3 stimulates aldosterone release.Subunit : During pregnancy, exists as a disulfide-linked 2:2 heterotetramer with the proform of PRG2 ａnd as a complex （probably a 2:2:2 heterohexamer） with pro-PRG2 ａnd C3dg.Subcellular Location : Secreted.Tissue Specificity : Expressed by the liver ａnd secreted in plasma.DISEASE : Genetic variations in AGT are a cause of susceptibility to essential hypertension （EHT） [MIM:145500]. Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause. Defects in AGT are a cause of renal tubular dysgenesis （RTD） [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria ａnd perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios （the Potter phenotype）.Similarity : Belongs to the serpin family.血管紧张素原（Angiotenogen, AT）是一种大分子糖蛋白和α2球蛋白广泛分布于血液循环、淋巴、脑、肾脏等组织。