本公司经销Androgen receptor，雄激素受体抗体，克隆类型为polyclonal，宿主来源是Rabbit，Androgen receptor雄激素受体抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0118R
英文名称：Anti-Androgen receptor
中文名称：雄激素受体抗体
其他名称：Androgen receptor; AR; HYSP1; AIS; DHTR; Androgen receptor （dihydrotestosterone receptor; testicular feminization; spinal ａnd bulbar muscular atrophy; Kennedy disease）; Dihydro Testosterone Receptor; Dihydrotestosterone receptor; HUMARA; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; Spinal ａnd bulbar muscular atrophy; TFM.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 110kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, hrs, shp, cow, pig, chk
产品介绍：Androgen receptor is a member of the steroid superfamily of ligand-dependent transcription factors. Like other members of the family, the androgen receptor consists of an amino terminal modulating domain, a central DNA binding domain, a hinge region ａnd a carboxy terminal ligand binding domain. The amino terminal regions of steroid receptors are highly variable in size ａnd amino acid composition while the DNA ａnd ligand binding domains exhibit substantial sequence homology.Function : Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression ａnd affect cellular proliferation ａnd differentiation in target tissues. Transcription factor activity is modulated by bound coactivator ａnd corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 ａnd ZIPK/DAPK3.Subunit : Binds DNA as a homodimer. Part of a ternary complex containing AR, EFCAB6/DJBP ａnd PARK7. Interacts with HIPK3 ａnd NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone. Interacts with EFCAB6/DJBP, PELP1, PQBP1, RANBP9, RBAK, SPDEF, SRA1, TGFB1I1, ZNF318 ａnd RREB1. Interacts with ZMIZ1/ZIMP10 ａnd ZMIZ2/ZMIP7 which both enhance its transactivation activity. Interacts with SLC30A9 ａnd RAD54L2/ARIP4 （By similarity）. Interacts via the ligand-binding domain with LXXLL ａnd FXXLF motifs from NCOA1, NCOA2, NCOA3, NCOA4 ａnd MAGEA11. The AR N-terminal poly-Gln region binds Ran resulting in enhancement of AR-mediated transactivation. Ran-binding decreases as the poly-Gln length increases. Interacts with HIP1 （via coiled coil domain）. Interacts （via ligand-binding domain） with TRIM68. Interacts with TNK2. Interacts with USP26. Interacts with RNF6. Interacts （regulated by RNF6 probably through polyubiquitination） with RNF14; regulates AR transcriptional activity. Interacts with PRMT2 ａnd TRIM24. Interacts with GNB2L1/RACK1. Interacts with RANBP10; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with PRPF6 in a hormone-independent way; this interaction enhances dihydrotestosterone-induced AR transcriptional activity. Interacts with STK4/MST1. Interacts with ZIPK/DAPK3. Interacts with LPXN. Interacts with MAK. Part of a complex containing AR, MAK ａnd NCOA3.Subcellular Location : Nucleus. Cytoplasm.Tissue Specificity : Isoform 2 is mainly expressed in heart ａnd skeletal muscle.Post-translational modifications : Sumoylated on Lys-386 （major） ａnd Lys-520. Ubiquitinated. Deubiquitinated by USP26. ＇Lys-6＇ ａnd ＇Lys-27＇-linked polyubiquitination by RNF6 modulates AR transcriptional activity ａnd specificity. Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase （CSK）. Tyr-534 is one of the major phosphorylation sites ａnd an increase in phosphorylation ａnd Src kinase activity is associated with prostate cancer progression. Phosphorylation by TNK2 enhances the DNA-binding ａnd transcriptional activity ａnd may be responsible for androgen-independent progression of prostate cancer. Phosphorylation at Ser-81 by CDK9 regulates AR promoter selectivity ａnd cell growth. Phosphorylation by PAK6 leads to AR-mediated transcription inhibition. Palmitoylated by ZDHHC7 ａnd ZDHHC21. Palmitoylation is required for plasma membrane targeting ａnd for rapid intracellular signaling via ERK ａnd AKT kinases ａnd cAMP generation. DISEASE : Defects in AR are the cause of androgen insensitivity syndrome （AIS） [MIM:300068]; previously known as testicular feminization syndrome （TFM）. AIS is an X-linked recessive form of pseudohermaphroditism due end-organ resistance to androgen. Affected males have female external genitalia, female breast development, blind vagina, absent uterus ａnd female adnexa, ａnd abdominal or inguinal testes, despite a normal 46,XY karyotype. Defects in AR are the cause of spinal ａnd bulbar muscular atrophy X-linked type 1 （SMAX1） [MIM:313200]; also known as Kennedy disease. SMAX1 is an X-linked recessive form of spinal muscular atrophy. Spinal muscular atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness ａnd atrophy. SMAX1 occurs only in men. Age at onset is usually in the third to fifth decade of life, but earlier involvement has been reported. It is characterized by slowly progressive limb ａnd bulbar muscle weakness with fasciculations, muscle atrophy, ａnd gynecomastia. The disorder is clinically similar to classic forms of autosomal spinal muscular atrophy. Note=Caused by trinucleotide CAG repeat expansion. In SMAX1 patients the number of Gln ranges from 38 to 62. Longer expansions result in earlier onset ａnd more severe clinical manifestations of the disease. Note=Defects in AR may play a role in metastatic prostate cancer. The mutated receptor stimulates prostate growth ａnd metastases development despite of androgen ablation. This treatment can reduce primary ａnd metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor. Defects in AR are the cause of androgen insensitivity syndrome partial （PAIS） [MIM:312300]; also known as Reifenstein syndrome. PAIS is characterized by hypospadias, hypogonadism, gynecomastia, genital ambiguity, normal XY karyotype, ａnd a pedigree pattern consistent with X-linked recessive inheritance. Some patients present azoospermia or severe oligospermia without other clinical manifestations. Similarity : Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain.类固醇受体（Steroid Receptors）AR（ Androgen Receptor；dihydro testosterone R ）是一个由920个氨基酸组成的蛋白质，位于雄激素靶组织细胞中或细胞表面上的特异分子部位或结构。AR在前列腺癌中起着重要的作用，研究表明AR的表达与组织分型形成一定的相关性 ，AR在高分化的肿瘤中表达较多，而在低分化的肿瘤中表达较少。用于前列腺癌的检测，指导临床治疗，目前可用于乳腺癌、食道癌等各项肿瘤的研究。产品图片Tissue/cell: human prostate tissue; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-Androgen receptor Polyclonal Antibody, Unconjugated（bs-0118R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） staining