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Anti-ABCG2/CD338三磷酸腺苷结合转运蛋白G超家族成员2抗体
点击次数：310发布时间：2012/12/26 3:09:05
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-0662R
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详细内容
货号：BY-0662R
英文名称：Anti-ABCG2/CD338
中文名称：三磷酸腺苷结合转运蛋白G超家族成员2抗体
其他名称：BCRP; BXP-21; ABC15; ABCG 2; ABCG2; ABCP; ATP-binding cassette sub-family G member 2; BCRP1; BMDP; Breast cancer resistance protein; CDw338; CDw338; CD338; antigen; EST157481; MGC102821; Mitoxantrone resistance associated protein; MRX; MXR; MXR1; Placenta-specific ATP-binding cassette transporter.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 72kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
产品介绍：An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin ａnd doxorubicin, display diminished intracellular accumulation of daunorubicin, ａnd manifest an ATP-dependent increase in the efflux of rhodamine 123.Breast Cancer Resistance Protein （BCRP） is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.Subunit : Monomer or homodimer; disulfide-linked.Subcellular Location : Cell membrane; Multi-pass membrane protein.Tissue Specificity : Highly expressed in placenta. Low expression in small intestine, liver ａnd colon.Similarity : Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer （TC 3.A.1.204） subfamily.Contains 1 ABC transmembrane type-2 domain.Contains 1 ABC transporter domain.Hematopoietic/Neural Stem Cell Marker （造血/神经干细胞标志物）
