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Anti-Agrin聚集蛋白抗体
点击次数：412发布时间：2012/12/26 3:09:37
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-1176R
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货号：BY-1176R
英文名称：Anti-Agrin
中文名称：聚集蛋白抗体
其他名称：AGRIN; Agrin proteoglycan; AGRN; FLJ45064; OTTHUMP00000044043.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 208kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Agrin is a neuronal aggregating factor that induces the aggregation of acetylcholine receptors ａnd other postsynaptic proteins on muscle fibers ａnd is crucial for the formation of the neuromuscular junction. Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors （nAChRs） ａnd other proteins during development at the neuromuscular junction. Agrin, MuSK ａnd Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface ａnd induces AChR aggregation. The central region contains two O-linked glycosylation sites ａnd a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain ａnd glycosaminoglycan attachment sites; increasing the predicted MW from 200kDa to ~600kDa.Subcellular Location : Secreted; extracellular space; extracellular matrix. Note: Synaptic basal lamina at the neuromuscular junction.神经元标志物（Neuron marker） 聚集蛋白 agrin 由运动神经分泌可诱导肌纤维的乙酰胆碱酯酶和乙酰胆碱受体聚集的蛋白；蛋白聚糖在发育中对于促进细胞间相互联系起着重要的作用。蛋白聚糖分布广泛，并与神经系统的发育具有密切关系。
