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Anti-ACY1/Aminoacylase 1氨基酰化酶1抗体
点击次数：215发布时间：2012/12/26 3:21:02
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-6019R
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货号：BY-6019R
英文名称：Anti-ACY1/Aminoacylase 1
中文名称：氨基酰化酶1抗体
其他名称：ACY 1; ACY1; ACY1D; ACYLASE; EC 3.5.1.14; N acyl L amino acid amidohydrolase
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 46kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, cow
产品介绍：Aminoacylase 1 is a cytosolic, homodimeric, zinc binding enzyme that catalyzes the hydrolysis of acylated L amino acids to L amino acids ａnd acyl group, ａnd has been postulated to function in the catabolism ａnd salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small cell lung cancer （SCLC）, ａnd its expression has been reported to be reduced or undetectable in SCLC cell lines ａnd tumors. The amino acid sequence of human aminoacylase 1 is highly homologous to the porcine counterpart, ａnd ACY1 is the first member of a new family of zinc binding enzymes.Function : Involved in the hydrolysis of N-acylated or N-acetylated amino acids （except L-aspartate）.Subunit : Homodimer. Interacts with SPHK1.Subcellular Location : Cytoplasm.Tissue Specificity : Expression is highest in kidney, strong in brain ａnd weaker in placenta ａnd spleen.DISEASE : Defects in ACY1 are the cause of aminoacylase-1 deficiency （ACY1D） [MIM:609924]. ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis ａnd syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids.Similarity : Belongs to the peptidase M20A family.
