本公司经销ACVR1B/ALK4，激活素A受体1B抗体，克隆类型为polyclonal，宿主来源是Rabbit，ACVR1B/ALK4激活素A受体1B抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6018R
英文名称：Anti-ACVR1B/ALK4
中文名称：激活素A受体1B抗体
其他名称：Activin A receptor type 1B; Activin A receptor type II like kinase 4; Activin A type 1B receptor; Activin A type IB receptor; Activin receptor like kinase 4; Activin receptor type 1B; Activin receptor type IB; Activin receptor type-1B; Activin receptor-like kinase 4; ACTR IB; ACTR-IB; ACTRIB; ACV1B_HUMAN; ACVR 1B; ACVR1B; ACVRLK 4; ACVRLK4; ALK 4; ALK-4; ALK4; Serine（threonine） protein kinase receptor R2; Serine/threonine-protein kinase receptor R2; SKR 2; SKR2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 53kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, hrs, pig, hrs, dog, Rb
产品介绍：[FUNCTION]Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 （ACVR2A or ACVR2B）. Transduces the activin signal from the cell surface to the cytoplasm ａnd is thus regulating a many physiological ａnd pathological processes including neuronal differentiation ａnd neuronal survival, hair follicle development ａnd cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression ａnd carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors （ACVR2A and/or ACVR2B） act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane ａnd activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates ａnd activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds ａnd phosphorylates the SMAD proteins SMAD2 ａnd SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor ａnd subsequent phosphorylation, SMAD2 ａnd SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 ａnd SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.Subunit : Forms an activin receptor complex with activin receptor type-2 （ACVR2A or ACVR2B）. Interacts with TDP2 （By similarity）.Subcellular Location : Cell membrane; Single-pass type I membrane protein.Tissue Specificity : Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, ａnd liver.Similarity : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.