本公司经销ASAH2，酰基鞘氨醇脱酰酶2抗体，克隆类型为polyclonal，宿主来源是Rabbit，ASAH2酰基鞘氨醇脱酰酶2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6021R
英文名称：Anti-ASAH2
中文名称：酰基鞘氨醇脱酰酶2抗体
其他名称：Acylsphingosine deacylase 2; ASAH2; ASAH2_HUMAN; BCDase; hCD; HNAC1; LCDase; MGC129777; mitochondrial ceramidase; N acylsphingosine amidohydrolase （non lysosomal ceramidase） 2; N acylsphingosine amidohydrolase 2; N CDase; N-acylsphingosine amidohydrolase 2; N-CDase; NCDase; Neutral ceramidase soluble form; Non lysosomal ceramidase; Non-lysosomal ceramidase.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 86kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, Rb
产品介绍：Hydrolyzes the sphingolipid ceramide into sphingosine ａnd free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, ａnd generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids ａnd regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.Function : Hydrolyzes the sphingolipid ceramide into sphingosine ａnd free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, ａnd generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids ａnd regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.Subcellular Location : Cell membrane; Single-pass type II membrane protein. Note=The neutral ceramidase soluble form is a secreted protein. According to PubMed:10781606, it is mitochondrial. However, they used a shorter form in its N-terminus, which may explain this localization which probably does not exist in vivo.Tissue Specificity : Primarily expressed in the intestine （PubMed:17334805）. Ubiquitously expressed with higher levels in kidney, skeletal muscle ａnd heart （PubMed:10781606）. According to PubMed:17334805, ubiquitous expression attributed to ASAH2 may be actually that of the paralog ASAH2B.Post-translational modifications : N-glycosylated. Required for enzyme activity （By similarity）.O-glycosylated. Required to retain it as a type II membrane protein at the cell surface.Phosphorylated. May prevent ubiquitination ａnd subsequent degradation （By similarity）.Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is triggered by nitric oxid （By similarity）.Similarity : Belongs to the neutral ceramidase family.