产品展示
Anti-ASB3锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3抗体
点击次数：309发布时间：2012/12/26 3:24:15
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-7736R
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详细内容
货号：BY-7736R
英文名称：Anti-ASB3
中文名称：锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3抗体
其他名称：Ankyrin repeat ａnd SOCS box containing 3; Ankyrin repeat ａnd SOCS box containing protein 3; Ankyrin repeat ａnd SOCS box protein 3; ASB-3; ASB3; ASB3_HUMAN; Weakly similar to ankyrin brain variant 2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 57kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow, Rb
产品介绍：Members of the suppressor of cytokine signaling （SOCS） family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins ａnd their binding partners with the elongin B ａnd C complex. Serveral other families of proteins also contain SOCS boxes but differ from the SOCS proteins in the type of domain they contained upstream of the SOCS box. Four members of the ankyrin repeat ａnd SOCS box-containing （ASB） protein family are identified ａnd termed as ASB-1, ASB-2, ASB-3 ａnd ASB-4. ASB-1 is expressed in multiple organs, including the hematopoietic compartment. ASB-1 knock-out mice display a diminution of spermatogenesis with less complete filling of seminiferous tubules. Asb-2 is a novel retinoic-acid （RA）-induced gene in acute promyelocytic leukemia （APL） cells ａnd its expression induces growth-inhibition ａnd chromatin condensation recapitulating early events critical to RA-induced differentiaiton of APL cells. ASB-2 is directly induced by all-trans retinotic acid, by the binding of RARa to the RAR binding element/RXR binding element in the Asb-2 promoter.Function : Probable substrate-recognition component of a SCF-like ECS （Elongin-Cullin-SOCS-box protein） E3 ubiquitin-protein ligase complex which mediates the ubiquitination ａnd subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.Subunit : Interacts with TCEB2 ａnd TNFRSF1B.Similarity : Contains 11 ANK repeats.Contains 1 SOCS box domain.
