本公司经销ARHGAP32，Rho GTP酶激活蛋白32抗体，克隆类型为polyclonal，宿主来源是Rabbit，ARHGAP32Rho GTP酶激活蛋白32抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-9296R
英文名称：Anti-ARHGAP32
中文名称：Rho GTP酶激活蛋白32抗体
其他名称：Brain-specific Rho GTPase-activating protein; GAB-associated Cdc42/Rac GTPase-activating protein; GC-GAP; GRIT; GTPase regulator interacting with TrkA; p200RhoGAP; p250GAP; PX-RICS; rac GTPase activating protein; Rho GTPase activating protein 32; Rho GTPase-activating protein 32; Rho-type GTPase-activating protein 32; Rho/Cdc42/Rac GTPase-activating protein RICS; RhoGAP involved in the beta-catenin-N-cadherin ａnd NMDA receptor signaling; RICS.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 230kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, dog, cow
产品介绍：ARHGAP32 is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology ａnd strength by modulating Rho GTPase.Function : GTPase-activating protein （GAP） promoting GTP hydrolysis on RHOA, CDC42 ａnd RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- ａnd Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity （By similarity）.Subunit : nteracts with NTRK1 （via cytoplasmic domain）; the interaction is independent of the phosphorylation state of NTRK1. Interacts with SHC3 （via SH2 domain）. Interacts with RASA1 （via SH3 domain）; the interaction is necessary for the Ras activation ａnd cell transforming activities of ARHGAP32 （By similarity）. Interacts with GAB1 ａnd GAB2. Interacts with CRK ａnd CRKL. Found in a complex with CRKL ａnd BCAR1; upon EGF stimulation BCAR1 may be replaced by EGFR. Interacts with NCK1 （via SH3 domain）; NCK1 recruits phosphorylated BCAR1 to the complex. Isoform 2 interacts with FYN; the interaction appears to be dependent on tyrosine phosphorylation of ARHGAP32. Interacts with EGFR; the interaction requires EGF stimulation ａnd is increased by SHC3. Interacts with CDC42; the interaction requires constitutively active CDC42. Interacts with CTNNB1, DLG4, CDH2 ａnd GRIN2B （By similarity）.Subcellular Location : Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendritic spine By similarity. Cytoplasm, cell cortex. Endosome membrane By similarity. Golgi apparatus membrane By similarity. Endoplasmic reticulum membrane By similarity. Membrane.Tissue Specificity : Isoform 1 ａnd isoform 2 are highly expressed in brain ａnd testis. Isoform 1 is also expressed in other tissues such as lung, liver ａnd spleen.Post-translational modifications : Isoform 2 is phosphorylated on multiple tyrosine residues by FYN. Phosphorylated tyrosine residues undergo dephosphorylation after stimulation of NMDA receptors （By similarity）. Phosphorylated in vitro by CaMK2 in the presence of calmodulin ａnd calcium; which inhibits GAP activity （By similarity）.Similarity : Belongs to the PX domain-containing GAP family.Contains 1 PX （phox homology） domain. Contains 1 Rho-GAP domain.Contains 1 SH3 domain.