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Anti-ASGPR1/ASGR1唾液酸糖蛋白受体1抗体
点击次数：622发布时间：2012/12/26 3:30:56
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-4119R
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货号：BY-4119R
英文名称：Anti-ASGPR1/ASGR1
中文名称：唾液酸糖蛋白受体1抗体
其他名称：ASGR; Asgr1; ASGPR1; Asgr; Asgr-1: MGC108731; RATRHL1; RHL1.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 32kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, cow, hrs, Rb
产品介绍：ASGR is a heterooligomeric receptor that is abundantly expressed on the sinusoidal surface of the hepatic plasma membrane. It is an endocytic receptor that rapidly binds ａnd internalizes galactose-terminated glycoproteins （asialoglycoproteins or ASGP） from the circulation. The mouse ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked ａnd highly homologous subunits, a major 42 kDa glycoprotein ASGPR1（MHL-1） ａnd a minor 51 kDa glycoprotein ASGR2 （MHL-2）. ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, ａnd an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, ａnd the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The aa sequence of mouse ASGPR1 ECD is 89% ａnd 79% identical to the ASGPR1 ECD of rat ａnd human, respectively.Subunit : Interacts with LASS2.Subcellular Location : Membrane; Single-pass type II membrane protein.Tissue Specificity : Expressed exclusively in hepatic parenchymal cells.Similarity : Contains 1 C-type lectin domain.
