产品展示
Anti-ACPT睾丸酸性磷酸酶抗体
点击次数：222发布时间：2012/12/26 3:34:47
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-6289R
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详细内容
货号：BY-6289R
英文名称：Anti-ACPT
中文名称：睾丸酸性磷酸酶抗体
其他名称：Acid phosphatase testicular; Testicular acid phosphatase.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 47kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, hrs
产品介绍：Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is upregulated by androgens ａnd is down-regulated by estrogens in the prostate cancer cell line. ACPT dephosphorylates receptor tyrosine-protein kinase erbB-4 ａnd inhibits the ligand-induced proteolytic cleavage. ACPT is predominantly expressed in testis but exhibits a lower level of expression in testicular cancer tissues than in normal tissues. ACPT has structural similarity to prostatic ａnd lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.Subcellular Location : Membrane; Single-pass type II membrane protein （Potential）.Tissue Specificity : High levels in pancreatic, gastric, colorectal ａnd ampullary cancer. Very weak expression in normal gastrointestinal ａnd urogenital tract.Similarity : Belongs to the peptidase S1 family.Contains 1 LDL-receptor class A domain.Contains 1 peptidase S1 domain.Contains 1 SRCR domain.
