本公司经销A4GALT/CD77，α1,4-半乳糖基转移酶1，克隆类型为polyclonal，宿主来源是Rabbit，A4GALT/CD77α1,4-半乳糖基转移酶1可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-7588R
英文名称：Anti-A4GALT/CD77
中文名称：α1,4-半乳糖基转移酶1
其他名称：4 N acetylglucosaminyltransferase; 4-galactosyltransferase; 4-N-acetylglucosaminyltransferase; A14GALT; A4GALT; A4GALT1; A4GAT_HUMAN; Alpha 1 4 galactosyltransferase; Alpha 1 4 N acetylglucosaminyltransferase; Alpha-1; Alpha-1; Alpha4Gal T1; Alpha4Gal-T1; CD 77; CD77 synthase; GB3 synthase; Gb3S; Globotriaosylceramide synthase; Lactosylceramide 4 alpha galactosyltransferase; Lactosylceramide 4-alpha-galactosyltransferase; P blood group （P one antigen）; P（k） antigen synthase; P1; P1/Pk synthase; PK; UDP galactose beta D galactosyl beta1 R 4 alpha D galactosyltransferase; UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 40kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, pig, chk
产品介绍：Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide ａnd galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.Expression of CD77, also called Gb3, sensitizes a cell to verotoxins, causing cellular injury that can lead to disease. Therefore, the complex regulation of CD77 biosynthesis ａnd the activity of the enzymes involved, such as CD77 synthase, can be studied by compared gene expression between toxin-sensitive ａnd insensitive tissues ａnd cell lines. The highest tissue expression of CD77 synthase occurs in the kidney, mesenteric lymph node, spleen, ａnd brain. Burkitt leukemia cells express very high levels of CD77 as well as CD77 synthase, ａnd are sensitive to verotoxin induced apoptosis. These megakaryoblasts then never mature, leading to the arrest of platelet generation in the bone marrow, which may cause thrombocytopenia, a symptom associated with various hemorrhagic conditions.Function : Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide ａnd galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.Subcellular Location : Golgi apparatus membrane; Single-pass type II membrane protein （Probable）.Tissue Specificity : Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis ａnd placenta.Similarity : Belongs to the glycosyltransferase 32 family.