产品展示
Anti-ARIP2a激活素受体2A抗体
点击次数：174发布时间：2012/12/26 3:43:10
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-0804R
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详细内容
货号：BY-0804R
英文名称：Anti-ARIP2a
中文名称：激活素受体2A抗体
其他名称：Activin receptor 2A; Activin receptor type 2A; ACTR 2; ACTR IIA; ACTR2; ActRIIa; Acvr 2; Acvr 2A; Acvr2; Acvr2a; OTTHUMP00000197918.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 57kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, chk, cow, dog, shp, Rb
产品介绍：Activins are dimeric growth ａnd differentiation factors which belong to the transforming growth factor-beta （TGF-beta） superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I （I ａnd IB） ａnd two type II （II ａnd IIB） receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, ａnd a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; ａnd type II receptors are required for binding ligands ａnd for expression of type I receptors. Type I ａnd II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. Activin has been suggested to be an autocrine/paracrine regulator in the human placenta. The presence of ACVR2 mRNA has been deomnstrated in human trophoblast cells ａnd there is also evidence of expression of the gene in human brain ａnd ovary.激活素受体ⅡA-ARIP2a属于ARIP家族新成员，在脑组织、垂体、睾丸中表达较高，胰腺、卵巢组织中有表达。
