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Anti-beta-Amyloid(1-40)β淀粉样肽（1-40）抗体
点击次数：165发布时间：2012/12/26 3:45:05
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-0106M
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货号：BY-0106M
英文名称：Anti-beta-Amyloid（1-40）
中文名称：β淀粉样肽（1-40）抗体
其他名称：A4; AAA; ABETA; ABPP; AD1; Alzheimers Disease Amyloid Protein; Amyloid B; Amyloid Beta A4 Protein Precursor; Amyloid Beta; Amyloid of Aging ａnd Alzheimer Disease; APP; APPI; B Amyloid; Beta APP; Cerebral Vascular Amyloid Peptide; CTFgamma; CVAP; PN II; PN2; PreA4; Protease nexin II; A beta; Amyloid 1-40.
抗体来源：Mouse
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 4.4kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, Rb, cow, dog, chk, pig, mo, rat
产品介绍：The cerebral ａnd vascular plaques associated with Alzheimer＇s disease are mainly composed of Amyloid beta peptides. beta Amyloid is derived from cleavage of the Amyloid precursor protein ａnd varies in length from 39 to 43 amino acids. beta Amyloid [1-40], beta Amyloid [1-42], ａnd beta Amyloid [1-43] peptides result from cleavage of Amyloid precursor protein after residues 40, 42, ａnd 43, respectively. The cleavage takes place by gamma-secretase during the last Amyloid precursor protein processing step. beta Amyloid [1-40], beta Amyloid [1-42], ａnd beta Amyloid [1-43] peptides are major constituents of the plaques ａnd tangles that occur in Alzheimer＇s disease. beta Amyloid antibodies ａnd peptides have been developed as tools for elucidating the biology of Alzheimer＇s disease.β-Amyloid 也称βA4 蛋白，是β-淀粉样蛋白前体（APP）经β和γ分泌酶分解后的产物，有39-43个氨基酸残基组成。是淀粉样蛋白的主要成分。β-淀粉样蛋白来自β-淀粉样蛋白原，在脑组织的细胞外呈丝状蛋白样沉积 ，是淀粉样结节性神经炎病变的主要蛋白成分，在神经纤维中也有沉积。在老年性痴呆Alzheimer病中，大脑皮质中特征性地出现β-淀粉样蛋白沉积形成的老年斑。主要用于老年性痴呆症病人大脑组织噬斑中淀粉样物质的检测。必要时石蜡组织切片用98-100%甲酸处理2-3分钟。
