本公司经销APOA1，载脂蛋白A1抗体，克隆类型为polyclonal，宿主来源是Rabbit，APOA1载脂蛋白A1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0849R
英文名称：Anti-APOA1
中文名称：载脂蛋白A1抗体
其他名称：Apolipoprotein A I; Apolipoprotein A 1; Apo AI; ApoA I; APOA1; APOA1/APOC3 fusion gene; Apo A1; Apo-A1; Apolipoprotein A I precursor; Apolipoprotein AI; Apolipoprotein of high density lipoprotein; ApolipoproteinAI; Brp14; Ltw1; Lvtw1; MGC117399; Sep1; Sep2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 27kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, cow, Rb, dog, chk
产品介绍：Apolipoprotein A I promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A I is the major protein component of high density lipoprotein （HDL） in the plasma. Synthesized in the liver ａnd small intestine, it consists of two identical chains of 77 amino acids; an 18 amino acid signal peptide is removed co-translationally ａnd a 6 amino acid propeptide is cleaved post-translationally. Apolipoprotein A I is a cofactor for lecithin cholesterolacyltransferase （LCAT） which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency ａnd Tangier disease.The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases.Subunit : Interacts with APOA1BP ａnd CLU. Component of a sperm activating protein complex （SPAP）, consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain ａnd albumin. Interacts with NDRG1.Subcellular Location : Secreted.Tissue Specificity : Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver ａnd small intestine. The oxidized form at Met-110 ａnd Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype ａnd exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I ａnd increased levels are seen with increasing severity of disease.Similarity : Belongs to the apolipoprotein A1/A4/E family.APOA1是检测高密度脂蛋白的主要形式，APOA1降低被认为是心、脑血管疾病的危险因素。 APOA1升高：常见于肝脏疾病、肝外胆道阻塞、人工透析。 APOA1降低：常见于冠心病、未控制的糖尿病、肾病综合征、营养不良、活动性肝炎、肝功能低下、动脉粥样硬化、高脂蛋白血症。产品图片Tissue/cell: chicken intestine tissue; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-APOA1 Polyclonal Antibody, Unconjugated（bs-0849R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） staining