本公司经销APBB1/Fe65 protein，铁蛋白Fe65抗体，克隆类型为polyclonal，宿主来源是Rabbit，APBB1/Fe65 protein铁蛋白Fe65抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0110R
英文名称：Anti-APBB1/Fe65 protein
中文名称：铁蛋白Fe65抗体
其他名称：Adaptor protein FE65a2; Amyloid beta （A4） precursor protein binding family B member 1; Amyloid beta A4 precursor protein binding family B; Amyloid beta A4 precursor protein binding family B member 1; Amyloid beta precursor protein binding family B member 1; APBB 1; APBB1; FE 65; Fe65 protein; MGC 9072; MGC9072; Protein Fe65; RIR; Stat like protein; Fe-65 Protein.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 90kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb
产品介绍：Amyloid precursor protein （APP）, which plays a central role in the pathogenesis of Alzheimer＇s disease （AD）, is a cell-surface protein that is cleaved by gamma-secretase at the transmembrane region into an extracellular amyloid-beta peptide （Ab） ａnd an intracellular tail fragment. This cytoplasmic tail of APP forms a multimeric complex with the nuclear adaptor protein FE65 ａnd the histone acetyltransferase Tip60.1 FE65 is an adaptor protein that bridges APP to certain molecular pathways. FE65 is also highly expressed in neurons ａnd possesses the characteristics of a transcription factor. The interaction between APP ａnd FE65 increases the translocation of APP to the cell surface ａnd the subsequent secretion of Ab. FE65 is thus important in the regulation ａnd trafficking of APP.Function : Transcription coregulator that can have both coactivator ａnd corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein （APP） intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus ａnd inducing apoptosis. May act by specifically recognizing ａnd binding histone H2AX phosphorylated on ＇Tyr-142＇ （H2AXY142ph） at double-strand breaks （DSBs）, recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks （DSBs）. Its ability to specifically bind modified histones ａnd chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET ａnd HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site（s）.Subunit : Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 ａnd APP. Interacts （via PID domain 2） with APP （with the intracellular domain of the beta-amyloid precursor protein）. Interacts （via PID domain 2） with RASD1/DEXRAS1; impairs the trancription activation activity. Interacts （via PID domain 1） with KAT5/TIP60. Interacts （via the WW domain） with the proline-rich region of APBB1IP. Interacts with TSHZ1 ａnd TSHZ2 （By similarity）. Interacts （via the WW domain） with histone H2AX （when phosphorylated on ＇Tyr-142＇） ａnd the proline-rich region of ENAH. Interacts with MAPK8. Interacts （via PID domain 1） with TSHZ3 （via homeobox domain）. Interacts with SET. Found in a trimeric complex with HDAC1 ａnd TSHZ3; the interaction between HDAC1 ａnd APBB1 is mediated by TSHZ3. Interacts （via WWW domain） with NEK6. Interacts （via WWW domain） with ABL1.Subcellular Location : Cell membrane. Cytoplasm. Nucleus. Cell projection, growth cone （By similarity）. Nucleus speckle. Note=Colocalizes with TSHZ3 in axonal growth cone （By similarity）. In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP. Following exposure to DNA damaging agents, it is released from cell membrane ａnd translocates to the nucleus. Nuclear translocation is under the regulation of APP. Colocalizes with TSHZ3 in the nucleus. Co-localizes with NEK6 at the nuclear speckles. Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus （By similarity）.Tissue Specificity : Highly expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.Post-translational modifications : Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus （By similarity）. Phosphorylated following nuclear translocation. Phosphorylation at Tyr-547 by ABL1 enhances transcriptional activation activity ａnd reduces the affinity for RASD1/DEXRAS1.Similarity : Contains 2 PID domains.Contains 1 WW domain.Fe65 蛋白（又称作Amyloid beta A4 precursor protein-binding family B member 1）可能与细胞内的APP结构域结合调节内源性的APP。产品图片Antigen: bs-0110P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.