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Anti-AKAP12/Gravin丝氨酸抑制蛋白激酶C底物抗体
点击次数：260发布时间：2012/12/26 3:47:54
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-1381R
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货号：BY-1381R
英文名称：Anti-AKAP12/Gravin
中文名称：丝氨酸抑制蛋白激酶C底物抗体
其他名称：A kinase （PRKA） anchor protein （gravin） 12; A kinase Anchor Protein 12; A kinase anchor protein 250kDa; AKAP 12; AKAP 250; AKAP250; DKFZp686M0430; DKFZp686O0331; Gercelin; Gravin; Kinase scaffold protein gravin; Myasthenia gravis autoantigen gravin; Srcs5; SSeCKS; Tsga12.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 185kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog
产品介绍：Gravin （also known as A Kinase Anchor Protein 12, AKAP12） was cloned from a cDNA expression library screened with serum, from a myasthenia gravis patient. Antibodies to Gravin were found in 22 out of 72 myasthemia gravis patients ａnd absent in sera of normal individuals. This protein is a myristoylated high molecular weight cytoplasmic protein expressed in endothelial cells, cultured fibroblasts ａnd osteosarcoma cells ａnd highly expressed in the brain. Gravin can bind kinases like PKA ａnd PKC by different domains of the protein ａnd can localize these kinases to specific domains in the cell. Upon differentiation of NT2 cells to neurons （NT2 N）, Gravin expression is up regulated ａnd enriched at the inner peripheral cortex in close proximity to the plasma membrane. In differentiated cells, gravin is co-localized with PKCbII, PKCa ａnd PKA. Decreased binding of PKCa to gravin was found after activation of PKC.
