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Anti-APG4B/AUTL1自噬相关蛋白4B抗体
点击次数：221发布时间：2012/12/26 3:48:20
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-1384R
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货号：BY-1384R
英文名称：Anti-APG4B/AUTL1
中文名称：自噬相关蛋白4B抗体
其他名称：APG4B; ATG4 autophagy related 4 homolog B （S. cerevisiae）; AUT like 1 cysteine endopeptidase; AUTL1; Autophagin 1; Autophagy related cysteine endopeptidase 1; Autophagy related protein 4 homolog B; Cysteine protease ATG4B; hAPG4B; MGC1353br.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 44kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow
产品介绍：ATG4B is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form （form II）. Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine （PE）-conjugated form, ａnd has the capacity for the binding to autophagosomes. Function : Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form （form II）. Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine （PE）-conjugated form, ａnd has the capacity for the binding to autophagosomes.Subcellular Location : Cytoplasm （Probable）.Tissue Specificity : Mainly expressed in the skeletal muscle, followed by brain, heart, liver ａnd pancreas.Similarity : Belongs to the peptidase C54 family.细胞自噬（Autophagy）是一种非凋亡性的程序性细胞死亡即自噬性程序性细胞死亡，进化过程中高度保守，清除降解细胞内受损伤的细胞结构、衰老的细胞器、以及不再需要的生物大分子等，在细胞的生长、发育和疾病发生中起着重要的作用。细胞自噬是一个高效调控过程，特异性激酶和鸟嘌呤核苷酸磷酸酶（GTPases）在调节自噬通道活性中起着关键作用.
