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货号：BY-8585R
英文名称：Anti-Arginase 1
中文名称：精氨酸酶1抗体
其他名称：ARG 1; ARG1; ARGI1_HUMAN; Arginase1; Arginase liver; Arginase type I; Arginase I; ArginaseI; Arginase-1; Arginase1; Liver type arginase; Liver-type arginase; Type I arginase.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 35kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Arginase I which is expressed almost exclusively in the liver, catalyzes the conversion of arginine to ornithine ａnd urea . The human arginase I gene, which maps to chromosome 6q23, encodes a 322 amino acid protein. Arginase I exists as a homotrimeric protein ａnd contains a binuclear manganese cluster. Arginase II catalyzes the same reaction as arginase I, but differs in its tissue specificity ａnd subcellular location. Specifically, arginase II localizes to the mitochondria. Arginase II is expressed in non-hepatic tissues, with the highest levels of expression in the kidneys, but, unlike arginase I, is not expressed in liver. The human arginase II gene, which maps to chromosome 14q24.1-q24.3, encodes a 354 amino acid protein. In addition, arginase II contains a putative amino-terminal mitochondrial localization sequence.Subcellular Location : Cytoplasm.DISEASE : Defects in ARG1 are the cause of argininemia （ARGIN） ; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood ａnd cerebrospinal fluid, ａnd periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.
