本公司经销Ankyrin B/Ankyrin brain，锚定蛋白B抗体，克隆类型为polyclonal，宿主来源是Rabbit，Ankyrin B/Ankyrin brain锚定蛋白B抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6967R
英文名称：Anti-Ankyrin B/Ankyrin brain
中文名称：锚定蛋白B抗体
其他名称：ANK-2;Ank2;ANK2_HUMAN;Ankyrin 2;Ankyrin 2 brain;Ankyrin B;Ankyrin rythroid;ANKYRIN, NEURONAL;Ankyrin-2;Ankyrin-B;Brain ankyrin;Non-erythroid ankyrin.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 426kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Members of the Ankyrin family of proteins mediate the attachment of integral membrane proteins to the cytoskeleton. ANK1, ANK2 ａnd ANK3 genes encode for the proteins in this family, Ankyrin-1 （also designated Ankyrin R）, Ankyrin B ａnd Ankyrin G, respectively. The proteins are structured similarly each composed of an N-terminal domain with multiple ankyrin repeats, a highly conserved central spectrin binding domain, ａnd C-terminal regulatory domains which are susceptible to the most variance. Both Ankyrin B ａnd Ankyrin G are essential for normal neuronal functions. Ankyrin B, or brain Ankyrin is predominantly expressed in the plasma membrane of neurons as well as glial cells throughout the brain. Two transcripts have been described with alternative splicing resulting in additional isoforms. The Ankyrin B protein associates with the spectrin-actin network, mediates axon fasciculation, ａnd stabilizes axon bundles. Ankyrin B is required for coordinated assembly of Na/Ca exchanger, Na/K ATPase, ａnd inositol trisphosphate （InsP（3）） receptor at transverse-tubule/sarcoplasmic reticulum sites in cardiomyocytes.Function : Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase ａnd InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger ａnd beta-2-spectrin （SPTBN1） in the inner segment of rod photoreceptors. Required for expression ａnd targeting of SPTBN1 in neonatal cardiomyocytes ａnd for the regulation of neonatal cardiomyocyte contraction rate.Subunit : Interacts with RHBG ａnd SPTBN1.Subcellular Location : Cytoplasm, cytoskeleton. Membrane. Cytoplasm, myofibril, sarcomere, M line. Apical cell membrane. Cell membrane. Tissue Specificity : Present in plasma membrane of neurons as well as glial cells throughout the brain. Expressed in fetal brain ａnd in temporal cortex of adult brain. Also expressed in the inner segments of rod photoreceptors in retina.DISEASE : Defects in ANK2 are the cause of long QT syndrome type 4 （LQT4） [MIM:600919]; also known as sick sinus syndrome with bradycardia. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG ａnd polymorphic ventricular arrhythmias. They cause syncope ａnd sudden death in response to exercise or emotional stress. LQT4 displays many atypical features compared to classical long QT syndromes, including pronounced sinus bradycardia, polyphasic T waves ａnd atrial fibrillation. Cardiac repolarization defects may be not as severe as in classical LQT syndromes ａnd prolonged QT interval on EKG is not a consistent feature.Similarity : Contains 24 ANK repeats.Contains 2 death domains.Contains 2 ZU5 domains.Database links : UniProtKB/Swiss-Prot: Q01484.4