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Anti-ATP7A铜转运蛋白质α链抗体
点击次数：1009发布时间：2012/12/26 3:56:23
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-1572R
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货号：BY-1572R
英文名称：Anti-ATP7A
中文名称：铜转运蛋白质α链抗体
其他名称：ATP 7A; ATPase Copper Transporting Alpha Polypeptide; ATPase Cu++ transporting alpha polypeptide （Menkes syndrome）; ATPase Cu++ transporting alpha polypeptide; Copper pump 1; Copper transporting ATPase 1; Cu++ transporting P type ATPase; MC 1; MC1; Menkes disease-associated protein; Menkes syndrome; MK; MNK; OHS
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 163kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow, hrs, Rb
产品介绍：Copper-transporting ATPase 1 is an integral membrane protein cycling constitutively between the trans-golgi network ａnd the plasma membrane. It may supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells. Defects in ATP7A are the cause of Menkes syndrome; also known as kinky hair disease, an X-linked recessive disorder.Subunit : Monomer.Subcellular Location : Golgi apparatus. trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note: Cycles constitutively between the trans-Golgi network （TGN） ａnd the plasma membrane. Predominantly found in the TGN ａnd relocalized to the plasma membrane in response to elevated copper levels. Isoform 3: Cytoplasm. cytosol. Isoform 5: Endoplasmic reticulum.Tissue Specificity : Found in most tissues except liver. Isoform 3 is widely expressed including in liver cell lines. Isoform 1 is expressed in fibroblasts, choriocarcinoma, colon carcinoma ａnd neuroblastoma cell lines. Isoform 2 is expressed in fibroblasts, colon carcinoma ａnd neuroblastoma cell lines.Similarity : Belongs to the cation transport ATPase （P-type） （TC 3.A.3） family. Type IB subfamily.Contains 6 HMA domains.
