本公司经销Aggrecan1，软骨蛋白聚糖抗体，克隆类型为polyclonal，宿主来源是Rabbit，Aggrecan1软骨蛋白聚糖抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1223R
英文名称：Anti-Aggrecan1
中文名称：软骨蛋白聚糖抗体
其他名称：ACAN; AGC 1; AGC1; AGCAN; Aggrecan 1 （chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122）; Aggrecan 1; Aggrecan core protein; Aggrecan proteoglycan; Aggrecan structural proteoglycan of cartilage; Aggrecan1; ATEGQV; Aggrecan ARGxx; Cartilage specific proteoglycan core protein; Chondroitin sulfate proteoglycan 1 ; Chondroitin sulfate proteoglycan 1 large aggregating proteoglycan antigen identified by monoclonal antibody A0122; Chondroitin sulfate proteoglycan core protein 1; CSPG 1; CSPG1; CSPGCP; JSCATE; Large aggregating proteoglycan; MSK 16; MSK16; SEDK.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 79/250kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, cow, Rb, chk, hrs, dog
产品介绍：Aggrecan is a member of a family of large, aggregating proteoglycans （also including versican, brevican ａnd neurocan） which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, ａnd G3. Between the G1 ａnd G2 domains there is an interglobulin region （IGD）. The IGD region is the major site of cleavage by specific proteases like metalloproteinases （MMPs） ａnd aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis ａnd osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, ａnd axonal outgrowth in the CNS.Function : Aggrecan has been detected in neural precursor cells （neurospheres; Kabos et al, 2004） During differentiation, neurospheres downregulate Chondroitin sulfate proteoglycans （CSPGs）. Proliferating neural precursors synthesize lecticans, including aggrecan, which are downregulated with differentiation; suggesting a link between CSPGs ａnd CNS precursor biology.Subcellular Location : SecretedAggrecan是软骨细胞外基质的主要结构成分。它与胶原蛋白网络结合，维持软骨弹性、缓冲压力，承担负荷,并有自我润滑的性能。蛋白多糖的进行性丧失是骨性关节病发病主要原因。