本公司经销ASPP1，p53凋亡刺激蛋白1抗体，克隆类型为polyclonal，宿主来源是Rabbit，ASPP1p53凋亡刺激蛋白1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-1282R
英文名称：Anti-ASPP1
中文名称：p53凋亡刺激蛋白1抗体
其他名称：p53BP2 like; p85; PPP1R13B; apoptosis stimulating protein of P53 1; Apoptosis-stimulating of p53 protein 2; Tumor suppressor p53-binding protein 2; p53-binding protein 2; p53BP2; 53BP2; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 120kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, dog, chk, cow
产品介绍：iASPP （inhibitor of apoptosis stimulating protein of p53, RelA-associated inhibitor （RAI）, NFKap B-interacting protein 1, protein phosphatase 1 regulatory subunit 13-like, PPP1R13L） is the third member of the ASPP family of proteins. Unlike ASPP1 ａnd ASPP2, which interact with p53 ａnd enhance its ability to induce apoptosis, iASPP inhibits apoptosis induced by p53 overexpression. iASPP has been identified in a yeast-two hybrid screen as an interacting protein of the p65 subunit of NFKap B （RelA）,3 interacts with NFKap B in vivo, ａnd acts as an efficient inhibitor of HIV-1 gene expression in which both NFKap b ａnd Sp1 play major roles. iASPP expression is upregulated in human breast carcinomas expressing wild-type p53, ａnd gene overexpression may play an important role in the leukemogenesis and/or progression of acute leukemia. Alternate Names: apoptosis stimulating protein of P53 1; Apoptosis-stimulating of p53 protein 2; Tumor suppressor p53-binding protein 2; p53-binding protein 2; p53BP2; 53BP2; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51.p53凋亡刺激蛋白（apoptosis stimulating protein of p53，ASPP）家族是近年来发现的一个新蛋白家族，它包括3个成员：ASPP1、ASPP2和其中ASPP1和ASPP2能够与p53蛋白结合增强该蛋白的促进细胞凋亡的功能，发挥抑制肿瘤的作用；而iASPP与ASPP1和ASPP2的功能截然相反，它能够和ASPP1或ASPP2竞争性地与p53结合，抑制ASPP1或ASPP2的促进凋亡作用，具有癌基因的功能。三者的结构相似，但功能却完全不同，通过研究三者的关系、促进肿瘤细胞内ASPP1或ASPP2的高表达以及抑制iASPP的表达有可能促进肿瘤细胞的凋亡，成为肿瘤治疗的新靶点.产品图片Antigen: bs-1282P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.