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Anti-ASPP2/p53BP2P53凋亡刺激蛋白2抗体
点击次数：249发布时间：2012/12/26 4:00:04
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-1283R
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货号：BY-1283R
英文名称：Anti-ASPP2/p53BP2
中文名称：P53凋亡刺激蛋白2抗体
其他名称：Apoptosis-stimulating of p53 protein 2; Bbp; Bcl2-binding protein; NY-REN-51 antigen; p53-binding protein 2; p53BP2; PPP1R13A; TP53BP2; Tumor suppressor p53-binding protein 2; apoptosis stimulating protein of P53 2.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 124kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, chk
产品介绍：This gene encodes a member of the ASPP（apoptosis-stimulating protein of p53 2） family of p53 interacting proteins. The protein contains four ankyrin repeats ａnd an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, ａnd regulates apoptosis ａnd cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. Regulator that plays a central role in regulation of apoptosis ａnd cell growth via its interactions. Regulates p53/TP53 by enhancing the DNA binding ａnd transactivation function of p53/TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, ａnd thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. [SUBCELLULAR LOCATION] Cytoplasm, perinuclear region. Nucleus. p53凋亡刺激蛋白（apoptosis stimulating protein of p53，ASPP）家族是近年来发现的一个新蛋白家族，它包括3个成员：ASPP1、ASPP2和iASPP。其中ASPP1和ASPP2能够与p53蛋白结合增强该蛋白的促进细胞凋亡的功能，发挥抑制肿瘤的作用；而iASPP与ASPP1和ASPP2的功能截然相反，它能够和ASPP1或ASPP2竞争性地与p53结合，抑制ASPP1或ASPP2的促进凋亡作用，具有癌基因的功能。三者的结构相似，但功能却完全不同，通过研究三者的关系、促进肿瘤细胞内ASPP1或ASPP2的高表达以及抑制iASPP的表达有可能促进肿瘤细胞的凋亡，成为肿瘤治疗的新靶点.
