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货号：BY-2113R
英文名称：Anti-AU5 tag
中文名称：
其他名称：
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：
纯化方法：affinity purified by Protein A
交叉反应：AU5 tagged fusion protein
产品介绍：Core protein packages viral RNA to form a viral nucleocapsid, ａnd promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES ａnd 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways ａnd apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta （IFN-alpha/beta） ａnd IFN-gamma signaling pathways ａnd by inducing human STAT1 degradation. Plays an important role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, ａnd activates STAT3 leading to cellular transformation. May repress the promoter of p53, ａnd sequester CREB3 ａnd SP110 isoform3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses ａnd in the immune response: suppresses NK-kappaB activation, ａnd activates AP-1. Mediates apoptotic pathways throught association with TNF-type receptors TNFRSF1A ａnd LTBR, although its effect on death receptors-induced apoptosis remains controvertial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Secreted core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, ａnd SV40 promoters. May suppress the human FOS ａnd HIV-1 LTR activity. May alter lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation ａnd storage."
