本公司经销phospho-ATF2 （Thr53），磷酸化活化复制因子2抗体，克隆类型为polyclonal，宿主来源是Rabbit，phospho-ATF2 （Thr53）磷酸化活化复制因子2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-8449R
英文名称：Anti-phospho-ATF2 （Thr53）
中文名称：磷酸化活化复制因子2抗体
其他名称：ATF2（Phospho-Thr53）: CREB 2; HB 16;Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response Element Binding Protein 2; cAMP response element binding protein CRE BP1; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CRE BP1; CRE-BP; CREB 2; CREB2; CREBP1; Cyclic AMP dependent transcription factor ATF 2; Cyclic AMP-responsive.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 45kDa
纯化方法：affinity purified by Protein A
交叉反应：mo, rat, hu, Rb, hrs, cow
产品介绍：ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element （CRE） in the promoter of various viral ａnd cellular genes. Many of these genes are important in cell growth ａnd differentiation, ａnd in stress ａnd immune responses. ATF2 is a nuclear protein that binds DNA as a dimer ａnd can form dimers with members of the ATF/CREB ａnd Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination ａnd proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, ａnd UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase ａnd p38 MAP kinase. ATF2 is abundantly expressed in brain.Subunit : Binds DNA as a dimer ａnd can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 ａnd SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.Subcellular Location : Nucleus.Tissue Specificity : Abundant expression seen in the brain.Similarity : Belongs to the bZIP family. ATF subfamily.Contains 1 bZIP domain.Contains 1 C2H2-type zinc finger.