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Anti-Agpat2溶血磷脂酸酰基转移酶β抗体
点击次数：229发布时间：2012/12/26 4:05:36
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-5032R
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货号：BY-5032R
英文名称：Anti-Agpat2
中文名称：溶血磷脂酸酰基转移酶β抗体
其他名称：LPAAB; BSCL; BSCL1; EC 2.3.1.51; LPAAB; LPAAT beta; Lysophosphatidic acid acyltransferase beta; 1 acyl sn glycerol 3 phosphate acyltransferase beta; 1 acylglycerol 3 phosphate O acyltransferase 2; 1 AGP acyltransferase 2; 1 AGPAT2 antibody Berardinelli Seip congenital lipodystrophy.PLCB_HUMAN
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 30kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, pig, cow, hrs
产品介绍：Agpat2 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. It is located within the endoplasmic reticulum membrane ａnd converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in its have been associated with congenital generalized lipodystrophy （CGL）, or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue ａnd severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.Function : Converts lysophosphatidic acid （LPA） into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.Subcellular Location : Membrane; Multi-pass membrane protein Tissue Specificity : Expressed predominantly in heart ａnd liver.DISEASE : Defects in AGPAT2 are the cause of congenital generalized lipodystrophy type 1 （CGL1） [MIM:608594]; also known as Berardinelli-Seip congenital lipodystrophy type 1 （BSCL1） or Berardinelli-Seip syndrome. CGL1 is an autosomal recessive disorder characterized by marked paucity of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis ａnd early onset of diabetes.Similarity : Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
