本公司经销APOE3，载脂蛋白E3抗体，克隆类型为polyclonal，宿主来源是Rabbit，APOE3载脂蛋白E3抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-5039R
英文名称：Anti-APOE3
中文名称：载脂蛋白E3抗体
其他名称：AD2; APOE3; ApoEb; Apolipoprotein EIII; Apolipoprotein E.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 34kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, cow
产品介绍：Chylomicron remnants ａnd very low density lipoprotein（VLDL） remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells ａnd peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 ａnd APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia （HLP III）, in which increased plasma cholesterol ａnd triglycerides are the consequence of impaired clearance of chylomicron ａnd VLDL remnants. [provided by RefSeq].Function : Mediates the binding, internalization, ａnd catabolism of lipoprotein particles. It can serve as a ligand for the LDL （apo B/E） receptor ａnd for the specific apo-E receptor （chylomicron remnant） of hepatic tissues.Subcellular Location : Secreted.Tissue Specificity : Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins （VLDL） ａnd 1-2% of high density lipoproteins （HDL）. APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney ａnd muscle.Post-translational modifications : Synthesized with the sialic acid attached by O-glycosidic linkage ａnd is subsequently desialylated in plasma. O-glycosylated with core 1 or possibly core 8 glycans. Thr-307 is a minor glycosylation site compared to Ser-308.Glycated in plasma VLDL of normal subjects, ａnd of hyperglycemic diabetic patients at a higher level （2-3 fold）.Phosphorylation sites are present in the extracellular medium.DISEASE : Genetic variations in APOE are associated with Alzheimer disease type 2 （AD2） [MIM:104310]. It is a late-onset neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, ａnd deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques ａnd vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide （s）, derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments （CTFs） ａnd the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. Note=The APOE*4 allele is genetically associated with the common late onset familial ａnd sporadic forms of Alzheimer disease. Risk for AD increased from 20% to 90% ａnd mean age at onset decreased from 84 to 68 years with increasing number of APOE*4 alleles in 42 families with late onset AD. Thus APOE*4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE*4 was virtually sufficient to cause AD by age 80. The mechanism by which APOE*4 participates in pathogenesis is not known.[DISEASE] Defects in APOE are a cause of sea-blue histiocyte disease （SBHD） [MIM:269600]; also known as sea-blue histiocytosis. This disorder is characterized by splenomegaly, mild thrombocytopenia and, in the bone marrow, numerous histiocytes containing cytoplasmic granules which stain bright blue with the usual hematologic stains. The syndrome is the consequence of an inherited metabolic defect analogous to Gaucher disease ａnd other sphingolipidoses.[DISEASE] Defects in APOE are a cause of lipoprotein glomerulopathy （LPG） [MIM:611771]. LPG is an uncommon kidney disease characterized by proteinuria, progressive kidney failure, ａnd distinctive lipoprotein thrombi in glomerular capillaries. It mainly affects people of Japanese ａnd Chinese origin. The disorder has rarely been described in Caucasians.Similarity : Belongs to the apolipoprotein A1/A4/E family.