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货号：BY-2390R
英文名称：Anti-Aconitase 2/ACO2
中文名称：铁调节蛋白2抗体
其他名称：ACO 2; ACO2; aconitase 2; Aconitase 2 mitochondrial; Aconitase; Aconitase2; Aconitate hydratase; Aconitate hydratase mitochondrial; ACONM; Citrate hydro lyase.
抗体来源：Rabbit
克隆类型：polyclonal克隆号85kDa
蛋白分子量：predicted molecular weight: 86kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, hrs, cow, pig, dog
产品介绍：ACO2, also referred to as aconitate hydratase, citrate hydrolyase or aconitase, is an iron-sulfur hydrolyase that catalyzes the non-limiting interconversion of citrate ａnd isocitrate in the tricarboxylic acid cycle. It is expressed in the mitochondria ａnd maintains a citrate:isocitrate ratio of approximately 10:1. ACO2 contains a redox-sensitive iron-sulfur cluster that exists in two states: active （Fe4S4） ａnd inactive （Fe3S4）. ACO2 activity is dependent on the state of this cluster as well as the presence of two conserved cysteine residues. In normal prostate epithelial cells ACO2 activity is prevented due to the high levels of zinc inhibiting the enzyme. In these citrate-producing epithelial cells citrate oxidation is impaired allowing citrate to accumulate ａnd exhibit a citrate:isocitrate ratio of approximately 30:1. In malignant prostate cells zinc is unable to accumulate, therefore ACO2 activity resumes ａnd citrate is oxidized. Subcellular Location : Mitochondrion.
