产品展示
Anti-ABCA1/ABC1腺苷三磷酸结合盒转运体A1抗体
点击次数：190发布时间：2012/12/26 4:22:33
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-1627R
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货号：BY-1627R
英文名称：Anti-ABCA1/ABC1
中文名称：腺苷三磷酸结合盒转运体A1抗体
其他名称：ATP binding cassette transporter A1; ABC 1; ABC Transporter 1; ABC1; ABCA 1; ABCA1; ATP binding Cassette 1; ATP binding cassette sub family A ABC1 member 1; ATP binding cassette sub family A member 1; ATP binding cassette sub-family A member 1; ATP binding Cassette Transporter 1; ATP-binding Cassette 1; ATP-binding Cassette Transporter 1; CERP; Cholesterol Efflux Regulatory Protein; FLJ14958; HDLDT1; Membrane bound; MGC164864; MGC165011; TD; TGD.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 254kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, dog
产品介绍：The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette （ABC） transporters. ABC proteins transport various molecules across extra- ａnd intracellular membranes. ABC genes are divided into seven distinct subfamilies （ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White）. This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier＇s disease ａnd familial high-density lipoprotein deficiency.Subunit : Interacts with MEGF10.Subcellular Location : Membrane; Multi-pass membrane protein.Tissue Specificity : Widely expressed in adult tissues. Highest levels are found in pregnant uterus ａnd uterus.Similarity : Belongs to the ABC transporter superfamily. ABCA family.Contains 2 ABC transporter domains. ABCA1是一种调节细胞内胆固醇流出的膜蛋白，其功能障碍将导致巨噬细胞内沉积大量的胆固醇而成为泡沫细胞，继而浸润血管壁，促进动脉粥样硬化的发生、发展。
