本公司经销Angiopoietin 2/ANG2，血管生成素2抗体，克隆类型为polyclonal，宿主来源是Rabbit，Angiopoietin 2/ANG2血管生成素2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0677R
英文名称：Anti-Angiopoietin 2/ANG2
中文名称：血管生成素2抗体
其他名称：AGPT 2; AGPT-2; Agpt2; ANG 2; ANG2; ANG-2; Angiopoietin 2a; Angiopoietin 2B; Angiopoietin2; Angiopoietin-2; ANGPT 2; ANGPT2; Tie2 ligand.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 53kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, dog, chk
产品介绍：Angiopoietin 1 ａnd Angiopoietin 2 are important for development of the endothelium, by regulating tyrosine phosphorylation of the membrane receptor Tie 2/Tek. Angiopoietin 2 is only 60% homologous with Angiopoietin 1. Angiopoietin 1 binding to Tie 2/Tek causes phosphorylation of the receptor. Angiopoietin 2 competes for this binding, ａnd thus blocks receptor phosphorylation. Angiopoietin 2 expression occurs at sites of vascular remodelling: dorsal aorta ａnd major aortic branches, ovary, placenta ａnd uterus.Function : Binds to TEK/TIE2, competing for the ANGPT1 binding site, ａnd modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration ａnd proliferation, thus serving as a permissive angiogenic signal.Subunit : Interacts with TEK/TIE2, competing for the same binding site as ANGPT1.Subcellular Location : Secreted.Similarity : Contains 1 fibrinogen C-terminal domain.血管生成素2（angiopoietin-2, Ang-2）是Ang家族的成员,是特异性血管生成刺激因子,也是恶性肿瘤早期的标志分子.产品图片Tissue/cell: rat lymphoma tissue; 4% Paraformaldehyde-fixed ａnd paraffin-embedded; Antigen retrieval: citrate buffer （ 0.01M, pH 6.0 ）, Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer （normal goat serum,C-0005） at 37℃ for 20 min; Incubation: Anti-Ang-2/Angiopoietin-2 Polyclonal Antibody, Unconjugated（bs-0677R） 1:200, overnight at 4°C, followed by conjugation to the secondary antibody（SP-0023） ａnd DAB（C-0010） staining