本公司经销ARA24，雄激素受体相关蛋白24抗体，克隆类型为polyclonal，宿主来源是Rabbit，ARA24雄激素受体相关蛋白24抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-3751R
英文名称：Anti-ARA24
中文名称：雄激素受体相关蛋白24抗体
其他名称：Ran; Androgen receptor associated protein 24; ARA 24; ARA24; Gsp1; GTP binding nuclear protein RAN; GTPase Ran; LPS; RAN member RAS oncogene family; Ras like protein TC4; Ras related nuclear protein; RASL2 8; TC 4; TC4.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 26kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow, chk, hrs, pig, Rb
产品介绍：Ran （ras-related nuclear protein） is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA ａnd proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis ａnd cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 （RCC1）. Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation ａnd organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of Ran-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor （AR） coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy＇s disease （X-linked spinal ａnd bulbar muscular atrophy）. Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, ａnd this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy＇s disease.Subunit : Monomer. Also forms a complex with CHC1 ａnd interacts with the AR N-terminal poly-Gln region.Subcellular Location : Nucleus. Cytoplasm. Melanosome.Tissue Specificity : Expressed in a variety of tissues.Ran是真核细胞中含量极丰富的小分子的GTP酶，在核转运过程中具有十分重要的作用。Ran主要参与了物质的核浆转运.