本公司经销Aph-1b，早老素稳定因子样蛋白/γ分泌酶组件蛋白APH1抗体，克隆类型为polyclonal，宿主来源是Rabbit，Aph-1b早老素稳定因子样蛋白/γ分泌酶组件蛋白APH1抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-11640R
英文名称：Anti-Aph-1b
中文名称：早老素稳定因子样蛋白/γ分泌酶组件蛋白APH1抗体
其他名称：Anterior pharynx defective 1;Anterior pharynx defective 1 homolog B （C. elegans）;Anterior pharynx defective 1 homolog B;Anterior pharynx defective 1B like;Anterior pharynx defective 1b short splicing variant;APH 1B;Aph 1beta;APH-1b;Aph-1beta;Aph1 beta;aph1b;APH1B_HUMAN;Aph1beta;Gamma secretase subunit APH 1B;Gamma secretase subunit APH1B;Gamma secretase sununit;Gamma-secretase subunit Aph-1b;Presenilin stabilisation factor like;Presenilin-stabilization factor-like;PRO 1328;PRO1328;PSFL;TAAV 688;TAAV688.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 28kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
产品介绍：Anterior pharynx defective 1 （Aph-1） is a polytopic, seven-pass membrane protein that functions as one of the four essential components in the presenilin-Gamma-secretase enzyme complex. This enzyme complex is necessary for the intra-membrane proteolysis of several different membrane proteins, including the beta-Amyloid precursor protein, ａnd is involved in multiple neurodevelopmental signaling pathways. Aph-1b ａnd Aph-1a are splice variants of Aph-1. Aph-1b specifically lacks exon 4, which encodes for the entire fourth transmembrane domain, causing the protein to be destabilized. Deficiency of Aph-1a causes a reduction in Gamma-secretase activity, however deficiency of Aph-1b does not; thus, Aph-1b may execute redundant functions in the cell. Aph-1b expression ａnd Gamma-secretase activity may be implicated in neurodevelopmental disorders, such as schizophrenia.Function : Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors ａnd APP （beta-amyloid precursor protein）. It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.Subcellular Location : Membrane.Tissue Specificity : Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart ａnd brain.Similarity : Belongs to the APH-1 family.