产品展示
Anti-AXL/UFO粘附相关激酶抗体
点击次数：206发布时间：2012/12/26 4:36:01
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-5180R
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详细内容
货号：BY-5180R
英文名称：Anti-AXL/UFO
中文名称：粘附相关激酶抗体
其他名称：Adhesion related kinase; Ark; AXL oncogene; AXL receptor tyrosine kinase; AXL transforming gene; AXL transforming sequence/gene; Oncogene AXL; Tyro7; Tyrosine protein kinase receptor UFO; UFO antibody.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 96kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, hrs, dog, pig, Rb
产品介绍：The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL ａnd FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors such as vitamin K dependent protein growth arrest specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia associated oncogene ａnd also associated with colon cancer ａnd melanoma.The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants （AXL1 ａnd AXL2）.Subunit : Heterodimer ａnd heterotetramer with ligand GAS6. Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2, PIK3R3, PLCG1, SOCS1 ａnd TENC1. Part a complex including AXL, TNK2 ａnd GRB2, in which GRB2 promotes AXL recruitment by TNK2.Subcellular Location : Cell membrane; Single-pass type I membrane protein.Tissue Specificity : Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. Contains 2 fibronectin type-III domains. Contains 2 Ig-like C2-type （immunoglobulin-like） domains. Contains 1 protein kinase domain
