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Anti-phospho-Androgen Receptor(Ser660)磷酸化雄激素受体抗体
点击次数：248发布时间：2012/12/26 4:40:08
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-5192R
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货号：BY-5192R
英文名称：Anti-phospho-Androgen Receptor（Ser660）
中文名称：磷酸化雄激素受体抗体
其他名称：HYSP1; AIS; Androgen receptor （dihydrotestosterone receptor; testicular feminization; spinal ａnd bulbar muscular atrophy; Kennedy disease）; AR; DHTR; Dihydro Testosterone Receptor; Dihydrotestosterone receptor; HUMARA; Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; Spinal ａnd bulbar muscular atrophy; TFM.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 101kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, pig, Rb
产品介绍：Androgen receptor （AR） belongs to the super-family of nuclear hormone receptors that employ complex molecular mechanisms to guide the development ａnd physiological functions of their target tissues. In mammals, exposure to androgens early in development is essential for masculinization of the male reproductive phenotype. Androgen stimulation results in cell proliferation in both the development of prostate ａnd malignant prostate. Data from animal ａnd human studies indicate that sex steroids have important skeletal effects. Androgens clearly enhance bone size, likely through effects on periosteal bone formation. Similarly to other steroid receptors, AR is a phosphoprotein, but the functional significance of the covalent receptor modification by phosphorylation has remained enigmatic.AR是一个由917个氨基酸组成的蛋白质，位于雄激素靶组织细胞中或细胞表面上的特异分子部位或结构。 AR在前列腺癌中起着重要的作用，研究表明AR的表达与组织分型形成一定的相关性 ，AR在高分化的肿瘤中表达较多，而在低分化的肿瘤中表达较少。用于前列腺癌的检测，指导临床治疗，目前可用于乳腺癌、食道癌等各项肿瘤的研究。
