本公司经销phospho-AQP2（Ser269），磷酸化水通道蛋白2抗体，克隆类型为polyclonal，宿主来源是Rabbit，phospho-AQP2（Ser269）磷酸化水通道蛋白2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-5187R
英文名称：Anti-phospho-AQP2（Ser269）
中文名称：磷酸化水通道蛋白2抗体
其他名称：ADH water channel; AQP 2; AQP CD; AQP2; AQPCD; Aquaporin 2 collecting duct; Aquaporin CD; Aquaporin2; Aquaporine 2; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; WCH CD; WCHCD.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 30kDa
纯化方法：affinity purified by Protein A
交叉反应：mo, rat, pig, dog, cow
产品介绍：This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant, ａnd recessive forms of nephrogenic diabetes insipidus. Belongs to the MIP/aquaporin （TC 1.A.8） family.Function : Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.Subcellular Location : Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane.Tissue Specificity : Expressed in renal collecting tubules.Post-translational modifications : Ser-256 phosphorylation is necessary ａnd sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent.DISEASE : Defects in AQP2 are the cause of diabetes insipidus nephrogenic autosomal （ANDI） [MIM:125800]; also known as diabetes insipidus nephrogenic type 2. ANDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking （polydypsia）, excessive urine excretion （polyuria）, persistent hypotonic urine, ａnd hypokalemia. Inheritance can be autosomal dominant or recessive.Similarity : Belongs to the MIP/aquaporin （TC 1.A.8） family.水通道蛋白-2特异地存在于肾脏集合管，受血管加压素调节。有研究证明，AQP2（水通道蛋白-2）在糖尿病肾脏集合管表达增强. 在1型糖尿病动物模型的水转运中尤其有意义。研究认为：AQP-2 奠定了糖尿病大鼠肾脏对水重吸收的基础，而且发现1型糖尿病病人的 AQP-2随血糖控制而减少。