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Anti-ATG18/WIPI1自噬相关蛋白18抗体
点击次数：269发布时间：2012/12/26 4:42:42
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-3871R
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货号：BY-3871R
英文名称：Anti-ATG18/WIPI1
中文名称：自噬相关蛋白18抗体
其他名称：ATG 18; ATG18; Atg18 protein homolog; ATG18A; WD repeat domain phosphoinositide interacting 1; WD repeat domain phosphoinositide interacting protein 1; WD40 repeat protein interacting with phosphoInositides of 49kDa; WIPI 1 alpha; WIPI 1; WIPI 49; WIPI 49 kDa ; WIPI49.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 49kDa
纯化方法：affinity purified by Protein A
交叉反应：mo, rat, hu, pig
产品介绍：Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1 （WD repeat domain, phosphoinositide interacting 1）, have a 7-bladed propeller structure ａnd contain a conserved motif for interaction with phospholipids. WIPI1 moved through the same set of endosomal membranes as that followed by mannose-6-phosphate receptor （MPR）. Consistent with this, WIPI1 was enriched in clathrin-coated vesicles. Overexpression of WIPI1 disrupted the function of the MPR pathway, whereas expression of a double point mutant unable to bind phosphoinositides had no effect. Suppression of WIPI1 by interfering RNA indicated that WIPI1 is required for normal endosomal organization ａnd distribution of IGF2R.
