本公司经销AT2R2，血管紧张素Ⅱ受体2抗体，克隆类型为polyclonal，宿主来源是Rabbit，AT2R2血管紧张素Ⅱ受体2抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-2133R
英文名称：Anti-AT2R2
中文名称：血管紧张素Ⅱ受体2抗体
其他名称：AGTR 2; AGTR2; AGTR-2; AGTR2_HUMAN; angiotensin II receptor type 2; Angiotensin II Type 2; Angiotensin II type-2 receptor; Angiotensin receptor 2; AT 2; AT2; AT2R2 ATGR 2; ATGR2; ATGR-2; MRX 88; MRX88; Type 2 angiotensin II receptor; Type-2 angiotensin II receptor.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 44kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, dog, shp, Rb
产品介绍：Angiotensin II （Ang II） is an important physiological effector of blood pressure ａnd volume regulation through vasoconstriction, aldosterone release, sodium uptake ａnd thirst stimulation. Although Ang II interacts with two types of cell surface receptors, AT1 ａnd AT2, most of the major cardiovascular effects seem to be mediated through AT1. Molecular cloning of the AT1 protein has shown it to be a member of the G protein-associated seven transmembrane protein receptor family. Ang II treatment of cells results in activation of several signal transduction pathways as evidenced by tyrosine phosphorylation of several proteins ａnd induction of others. PLC?is phosphorylated after 30 seconds of treatment with Angiotensin II, indicating this as an early signal transduction event. Ang II treatment also stimulates phosphorylation of Shc, FAK ａnd MAP kinases, ａnd induces MKP-1, indicating stimulation of growth factor pathways. Ang II stimulation through AT1 has been shown to activate the JAK/Stat pathway involving a direct interaction between JAK2 ａnd AT1 as demonstrated by coimmunoprecipitation. The AT1 receptor has no cytoplasmic kinase domain, but is able to function as a substrate for Src kinases ａnd has several putative phosphorylation sites.Function : Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation ａnd cell proliferation.Subcellular Location : Cell membrane.Tissue Specificity : In adult, highly expressed in myometrium with lower levels in adrenal gland ａnd fallopian tube. Very highly expressed in fetal kidney ａnd intestine.