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Anti-ADFP脂肪组织分化相关蛋白抗体
点击次数：232发布时间：2012/12/26 4:59:12
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-1164R
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货号：BY-1164R
英文名称：Anti-ADFP
中文名称：脂肪组织分化相关蛋白抗体
其他名称：adipophilin; Adipose differentiation related protein; ADRP; MGC10598
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 48kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
产品介绍：Milk lipid globules from humans, cows ａnd rats contain a protein identified as adipocyte differentiation-related protein （ADFP） associated with the globule surface membrane material. This protein, previously believed to be specific to adipocytes, was a major constituent of the globule surface ａnd was present in a detergent-insoluble complex that contained stoichiometric amounts of butyrophilin ａnd xanthine oxidase. ADFP （Adipophilin） occurs in a wide range of cultured cell lines, including fibroblasts, endothelial ａnd epithelial cells. In tissues, however, expression of adipophilin is restricted to certain cell types, such as lactating mammary epithelial cells, adrenal cortex cells, Sertoli ａnd Leydig cells of the male reproductive system, ａnd steatosis or fatty change hepatocytes in alcoholic liver cirrhosis. ADFP may be a possible new marker for the identification of specialized differentiated cells containing lipid droplets ａnd for diseases associated with fat-accumulating cells. Adipophilin（ADFP）是一种脂滴周围主要的相关蛋白，它大量分布在脂质蓄积正常或不正常的细胞中，是脂质蓄积的一个特异性标记物。它在脂肪细胞分化早期就有很高的表达，但当脂肪细胞成熟后，它的表达就明显减少，故称；脂肪分化相关蛋白。 ADFP在很多组织器官中都发挥重要作用，它不仅参与脂肪细胞的脂质代谢、脂滴的形成及肝内三酰甘油（TO）的合成与代谢，还能促进巨噬细胞、平滑肌细胞的泡沫化，长链脂肪酸的摄取，乳汁的分泌等。 ADFP的表达异常与动脉粥样硬化、胰岛素抵抗和肿瘤等病理过程密切相关。
