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Anti-Adiponectin脂联素抗体
点击次数：212发布时间：2012/12/26 5:00:28
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-0471R
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货号：BY-0471R
英文名称：Anti-Adiponectin
中文名称：脂联素抗体
其他名称：30 kDa adipocyte complement related protein; ACDC; ACRP 30; ACRP30; Adipocyte C1q ａnd collagen domain containing protein; Adipocyte complement related 30 kDa protein; Adipocyte complement related protein of 30 kDa; AdipoQ; Adipose most abundant gene transcript 1; APM 1; ApM1; GBP 28; GBP28; Gelatin binding protein.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 30kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, dog, pig, cow, chk, Rb
产品介绍：Adiponectin: A protein hormone produced ａnd secreted exclusively by adipocytes （fat cells） that regulates the metabolism of lipids ａnd glucose. Adiponectin influences the body＇s response to insulin. Adiponectin also has antiinflammatory effects on the cells lining the walls of blood vessels. High blood levels of adiponectin are associated with a reduced risk of heart attack. Low levels of adiponectin are found in people who are obese （and who are at increased risk of a heart attack）. Adipocytes produce ａnd secrete a number of proteins, including leptin, adipsin, properdin, ａnd tumor necrosis factor （TNF）. An adipose tissue-specific factor was isolated ａnd termed APM1 （AdiPose Most abundant gene transcript 1）. The protein product of APM1 is adiponectin. The APM1 gene maps to chromosome 3q27.脂联素又被称作Acrp30、apM1、AdipoQ、GBP28。 *初, 脂联素是在人体皮下脂肪组织、血浆和鼠科动物的脂肪细胞中被发现人体内的脂联素由244个氨基酸组成,分子量为27KD。 脂联素影响脂肪和糖类的代谢，还可以降低多种粘附分子（VCAM-1、ICAM-1、选择素-E） 在内皮细胞的表达。并影响着肿瘤坏死因子（TNF）分泌，近年来主要用于糖尿病的研究。 脂联素作为一种胰岛素超敏化激素（An Insulin–sensitizing Hormone）,可以增加促进骨骼肌细胞的脂肪酸氧化和糖吸收,明显加强胰岛素的糖元异生作用,抑制肝脏的糖生成,是机体的脂质代谢和血糖稳态的调控网络中的重要调节因子，在脂肪细胞分泌的具有生物活性的一类蛋白质因子中脂联素是脂肪组织基因表达*丰富的蛋白质产物,大量存在于血液循环中。在人体内以3-30ug/ml的浓度出现在循环血浆中。
