产品展示
Anti-ADM/AM/Adrenomedullin肾上腺髓质素抗体
点击次数：156发布时间：2012/12/26 5:00:53
更新日期：2024/9/5 14:43:27
所 在 地：其它
产品型号：BY-0007R
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详细内容
货号：BY-0007R
英文名称：Anti-ADM/AM/Adrenomedullin
中文名称：肾上腺髓质素抗体
其他名称：Adrenomedullin; ADM; ADM precursor; PAMP; Preproadrenomedullin; Proadrenomedullin N20 terminal peptide; ProAM N terminal 20 peptide; ProAM N20; ProAMN20.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 20kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, hrs, cow, dog, rat, mo
产品介绍：Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, ａnd shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of4 exons ａnd 3 introns, with the 5-prime flanking region containing TATA, CAAT, ａnd GC boxes. There are also multiple binding sites for activator protein-2 ａnd a cAMP-regulated enhancer element. Function : AM ａnd PAMP are potent hypotensive ａnd vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid ａnd electrolyte homeostasis. In the kidney, am is diuretic ａnd natriuretic, ａnd both am ａnd pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain ａnd pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.Subcellular Location : Secreted.Tissue Specificity : Highest levels found in pheochromocytoma ａnd adrenal medulla. Also found in lung, ventricle ａnd kidney tissues.Similarity : Belongs to the adrenomedullin family.肾上腺髓质素（Adrenomedullin， AM）是广泛分布在肾上腺髓质、肺、心、肝、肾等器官。
