本公司经销Aromatase，芳香化酶/细胞色素P450/雌激素合成酶抗体，克隆类型为polyclonal，宿主来源是Rabbit，Aromatase芳香化酶/细胞色素P450/雌激素合成酶抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-0114R
英文名称：Anti-Aromatase
中文名称：芳香化酶/细胞色素P450/雌激素合成酶抗体
其他名称：Cytochrome p450 19A1; Estrogen synthetase; ARO 1; ARO; ARO1; CPV; CYPXIX; Cytochrome P450 19A1; Cytochrome P450 family 19 subfamily A polypeptide 1; MGC104309; P 450AROM; P450AROM.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 20/24/40/57kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, dog, pig, Rb, shp, hrs
产品介绍：Aromatase is a key enzyme in steroidogenesis ａnd plays an important role in sexual differentiation, oestrogen biosynthesis, fertility ａnd carcinogenesis. It is highly conserved amongst mammals, ａnd is highly expressed in placental tissue. Many environmental chemicals may influence aromatase activity ａnd thereby disrupt endocrine function.Function : Catalyzes the formation of aromatic C18 estrogens from C19 androgens.Subcellular Location : Membrane; Peripheral membrane protein.Tissue Specificity : Brain, placenta ａnd gonads.DISEASE : Defects in CYP19A1 are a cause of aromatase excess syndrome （AEXS） [MIM:139300]; also known as familial gynecomastia. AEXS is characterized by an estrogen excess due to an increased aromatase activity.Defects in CYP19A1 are the cause of aromatase deficiency （AROD） [MIM:613546]. AROD is a rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia ａnd primary amenorrhoea with multicystic ovaries.Similarity : Belongs to the cytochrome P450 family.芳香化酶是一种微粒体酶系统，催化睾酮经三步连续强化转变成17-β-雌二醇,在反应中睾酮作为激素原。细胞色素P450主要分布在内质网和线粒体内膜上，作为一种末端加氧酶，参与了生物体内的甾醇类激素合成等过程。近年来，对细胞色素P450的结构、功能特别是对其在药物代谢中的作用的研究有了较大的进展。*新研究表明细胞色素P450还是药物代谢过程中的关键酶，而且对细胞因子和体温调节都有重要影响。芳香化酶-细胞色素P450作为和药物代谢及细胞因子相关的重要酶类，在药物代谢和免疫中起着相当重要的作用，对于它的研究将有助于新药的开发，并能帮助人们更加清楚的认识药物的代谢途径，在未来的新药中减少副作用，增加药物疗效。随着对细胞色素P450研究的深入，将有更多相关的药物代谢途径被发现，人们开发新药的视野将更加开阔，新药开发的速度也将加快，质量进一步提高。鉴于P450的研究无论在理论上探索生物的生理代谢、选择进化和生物与环境的关系方面,或在环境保护、农业生态、生物防治、作物基因工程和医药卫生等应用方面,都有广泛的实践意义,因此,应该受到更大的关注和重视。产品图片Antigen: bs-0114P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti- Rabbit IgG（bs-0295G-HRP） at 1: 5000; TMB（C-0024） staining; Read the data in MicroplateReader by 450nm.