本公司经销phospho-APE（Ser1417），磷酸化肌动蛋白结合蛋白Girdin抗体，克隆类型为polyclonal，宿主来源是Rabbit，phospho-APE（Ser1417）磷酸化肌动蛋白结合蛋白Girdin抗体可应用于WB、elisa、IP、IF、IHC等实验，欢迎垂询订购！

货号：BY-6465R
英文名称：Anti-phospho-APE（Ser1417）
中文名称：磷酸化肌动蛋白结合蛋白Girdin抗体
其他名称：Girdin （phospho S1417）; p-APE（Ser1417）; Akt phosphorylation enhancer; APE; Coiled coil domain containing protein 88A; G alpha interacting vesicle associated protein; Girders of actin filament; GIV; HkRP1; Hook related protein 1; AKT iphosphorylation enhancer; Akt phosphorylation enhancer; Ccdc88a; GIV; GRDN; GRDN_HUMAN; HkRP1; Hook related protein 1; Hook-related protein 1; KIAA1212.
抗体来源：Rabbit
克隆类型：polyclonal
蛋白分子量：predicted molecular weight: 206kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, dog, cow, hrs
产品介绍：Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development ａnd synapse formation. Enhances phosphoinositide 3-kinase （PI3K）-dependent phosphorylation ａnd kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 ａnd FOXO1/FKHR, ａnd regulates DNA replication ａnd cell proliferation （By similarity）. Essential for the integrity of the actin cytoskeleton ａnd for cell migration. Required for formation of actin stress fibers ａnd lamellipodia. May be involved in membrane sorting in the early endosome.Subunit : Interacts （via C-terminus） with DISC1; the interaction is direct. Interacts with AKT proteins; the interaction is inhibited in presence of DISC1. Homodimer. The non-phosphorylated form interacts with phosphatidylinositol 4-phosphate [PI（4）P] ａnd weakly with phosphatidylinositol 3-phosphate [PI（3）P]. Interacts with microtubules. Interacts with actin through its C-terminal domain. Interacts with the C-terminus of AKT1/PKB.Subcellular Location : Membrane. Cell membrane. Cytoplasm, cytosol. Cytoplasmic vesicle. Cell projection, lamellipodium. Note=Localizes to the cell membrane through interaction with phosphoinositides.Tissue Specificity : Expressed ubiquitously.Post-translational modifications : Phosphorylation is induced by epidermal growth factor （EGF） in a phosphoinositide 3-kinase （PI3K）-dependent manner. Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane ａnd for cell migration.Similarity : Belongs to the CCDC88 family.